BOC Sciences, the reputed supplier of amino acids, peptides, and resins, has gathered a large number of regular customers over the past decades. Apart from many top-qualified products, it also provides some critical services to comprehensively satisfy laboratorial and scientific needs.

In this article, several golden services regarding amino acid synthesis, labeling, and analysis will be introduced to guide researchers through finding out their desired assistance.

Custom Synthesis of Amino Acids

Peptide drugs have been on the market for the treatment of diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection, and chronic pain since the innovation of insulin a century ago. However, scientists are still struggling to overcome the problem of instability and reach the full potential of peptide drugs.

Studies have demonstrated that the introduction of unnatural amino acids into peptides can alleviate the problem or even increase drug activity, which encourages chemical suppliers to invest much energy in synthesizing varieties of amino acids. BOC Sciences currently employs the mature strategies of asymmetric synthesis, asymmetric catalytic hydrogenation, and chiral adjuvant-induced alkylation to obtain different amino acids. All the approaches are complementary to each other, enabling BOC Sciences to synthesize over 2000 amino acid derivatives or to provide customization upon receiving a request.

These custom amino acids are assured of a purity level from 95% to 99%. Besides, a series of analysis techniques, such as magnetic resonance, HPLC, IR, UV, and LCMS are applied, which will also be detailed in this article.

Chiral Resolution of Amino Acids

The D-type amino acids have broadened the application of antibiotics because the mixture of them would cause less resistance and degradation by bacteria. Among the 1,900 drugs being applied globally, chiral medicines account for half of them while most of the drugs under development are still chiral.

The above statistic data reveal that chiral resolution of amino acids, a critical step to avoid D-type amino acids poisoning, is highly crucial for drug production and discovery. BOC Sciences displays its strengths by offering a complete set of services including chemical, membrane, chromatographic, enzymatic, induced crystallization, extraction, and capillary electrophoresis resolution.

Stable Isotope Labeled Amino Acids

Stable isotope labeled amino acids are of great significance in the early diagnosis and treatment of patients suffering from neuropsychiatric diseases, cancers, and other illnesses. Its superiority is largely attributed to the application in magnetic resonance imaging to make metabolic changes visible in the body. Besides, stable isotope label amino acids are employed in many other industries, such as identification of food authenticity and origins, understanding the role of nitrogen fixation in the atmosphere, and quantification of specific metabolites found in complex matrices.

BOC Sciences' services involve research on regulation mechanism and mechanism in dynamic process, screening for disease, medication, and prognostic markers. In the aspect of technical services, BOC Sciences now provides cell isotope labeling, sample preparation and quantification, SDS-PAGE separation, liquid phase separation, and mass spectrometry analysis after trypsin digestion, etc.

Amino Acid Analysis

In recent years, a large proportion of attention is attached to amino acids analysis by global (bio)chemical suppliers. And BOC Sciences as a member of the pharmaceutical supply chain is no exception.

BOC Sciences possesses the current common instruments of ion exchange chromatography (IEC), high performance liquid chromatography (HPLC), or gas chromatography (GC), and are equipped with quality control chemistry methods, standardized software engineering, report templates, and qualification tools. Researchers who are in pursuit of precise and efficient analysis of amino acid samples will be satisfied with the final results.

Conclusion

As more potentials of amino acids are constantly uncovered, corresponding services should keep up or even exceed the current trend to support researchers' vast demands on amino acids.